Acyclic analogs of nucleosides. Synthesis of hydroxyalkyl derivatives of 2-trifluoromethyl- and 2-trifluoromethylthiobenzimidazole
Identifieur interne : 001544 ( Main/Exploration ); précédent : 001543; suivant : 001545Acyclic analogs of nucleosides. Synthesis of hydroxyalkyl derivatives of 2-trifluoromethyl- and 2-trifluoromethylthiobenzimidazole
Auteurs : A. É. Yavorskii [Russie] ; A. V. Stetsenko [Russie] ; I. V. Gogoman [Russie] ; V. N. Boiko [Russie] ; S. G. Zavgorodnii [Russie] ; A. I. Sobko [Russie] ; V. N. Tatskaya [Russie] ; V. G. Kvachev [Russie] ; V. L. Florent'Ev [Russie]Source :
- Chemistry of Heterocyclic Compounds [ 0009-3122 ] ; 1988-05-01.
English descriptors
- Teeft :
- Absolute acetonitrile, Acyclic, Acyclic analogs, Analog, Antivirus activity, Biological activity, Characteristic fragment ions, Cytopathogenic activity, Ester, Heterocyclic base, Khimiya geterotsiklicheskikh soedinenii, Mass spectra, Methanol solution, Mmole, Nucleoside, Nucleoside analogs, Original article, Potassium carbonate, Primary hydroxy groups, Relative intensity, Swine enterovirus, Trimethylsilyl derivatives, Triplet signals, Viia, Viib, Weak field.
Abstract
Abstract: 1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthiobenzimidazoles were obtained by condensation of trimethylsilyl derivatives of 2-substituted benzimidazoles with alkylating agents in the presence of SnCl4, or by direct alkylation of the sodium salts of the heterocycles.
Url:
DOI: 10.1007/BF00755691
Affiliations:
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Tatskaya</name><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Institute of Molecular Biology, Academy of Sciences of the USSR, 117984</wicri:orgArea></affiliation><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>All-Union Scientific-Research Institute of Biotechnology, Ministry of the Medical and Microbiological Industry of the USSR, 125047</wicri:orgArea></affiliation></author><author><name sortKey="Kvachev, V G" sort="Kvachev, V G" uniqKey="Kvachev V" first="V. G." last="Kvachev">V. G. Kvachev</name><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Institute of Molecular Biology, Academy of Sciences of the USSR, 117984</wicri:orgArea></affiliation><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>All-Union Scientific-Research Institute of Biotechnology, Ministry of the Medical and Microbiological Industry of the USSR, 125047</wicri:orgArea></affiliation></author><author><name sortKey="Florent Ev, V L" sort="Florent Ev, V L" uniqKey="Florent Ev V" first="V. L." last="Florent'Ev">V. L. Florent'Ev</name><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>Institute of Molecular Biology, Academy of Sciences of the USSR, 117984</wicri:orgArea></affiliation><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="3"><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName><wicri:orgArea>All-Union Scientific-Research Institute of Biotechnology, Ministry of the Medical and Microbiological Industry of the USSR, 125047</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Chemistry of Heterocyclic Compounds</title><title level="j" type="abbrev">Chem Heterocycl Compd</title><idno type="ISSN">0009-3122</idno><idno type="eISSN">1573-8353</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1988-05-01">1988-05-01</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="514">514</biblScope><biblScope unit="page" to="518">518</biblScope></imprint><idno type="ISSN">0009-3122</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0009-3122</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Absolute acetonitrile</term><term>Acyclic</term><term>Acyclic analogs</term><term>Analog</term><term>Antivirus activity</term><term>Biological activity</term><term>Characteristic fragment ions</term><term>Cytopathogenic activity</term><term>Ester</term><term>Heterocyclic base</term><term>Khimiya geterotsiklicheskikh soedinenii</term><term>Mass spectra</term><term>Methanol solution</term><term>Mmole</term><term>Nucleoside</term><term>Nucleoside analogs</term><term>Original article</term><term>Potassium carbonate</term><term>Primary hydroxy groups</term><term>Relative intensity</term><term>Swine enterovirus</term><term>Trimethylsilyl derivatives</term><term>Triplet signals</term><term>Viia</term><term>Viib</term><term>Weak field</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthiobenzimidazoles were obtained by condensation of trimethylsilyl derivatives of 2-substituted benzimidazoles with alkylating agents in the presence of SnCl4, or by direct alkylation of the sodium salts of the heterocycles.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Yavorskii, A E" sort="Yavorskii, A E" uniqKey="Yavorskii A" first="A. É." last="Yavorskii">A. É. Yavorskii</name></region><name sortKey="Boiko, V N" sort="Boiko, V N" uniqKey="Boiko V" first="V. N." last="Boiko">V. N. Boiko</name><name sortKey="Boiko, V N" sort="Boiko, V N" uniqKey="Boiko V" first="V. N." last="Boiko">V. N. Boiko</name><name sortKey="Florent Ev, V L" sort="Florent Ev, V L" uniqKey="Florent Ev V" first="V. L." last="Florent'Ev">V. L. Florent'Ev</name><name sortKey="Florent Ev, V L" sort="Florent Ev, V L" uniqKey="Florent Ev V" first="V. L." last="Florent'Ev">V. L. Florent'Ev</name><name sortKey="Gogoman, I V" sort="Gogoman, I V" uniqKey="Gogoman I" first="I. V." last="Gogoman">I. V. Gogoman</name><name sortKey="Gogoman, I V" sort="Gogoman, I V" uniqKey="Gogoman I" first="I. V." last="Gogoman">I. V. Gogoman</name><name sortKey="Kvachev, V G" sort="Kvachev, V G" uniqKey="Kvachev V" first="V. G." last="Kvachev">V. G. Kvachev</name><name sortKey="Kvachev, V G" sort="Kvachev, V G" uniqKey="Kvachev V" first="V. G." last="Kvachev">V. G. Kvachev</name><name sortKey="Sobko, A I" sort="Sobko, A I" uniqKey="Sobko A" first="A. I." last="Sobko">A. I. Sobko</name><name sortKey="Sobko, A I" sort="Sobko, A I" uniqKey="Sobko A" first="A. I." last="Sobko">A. I. Sobko</name><name sortKey="Stetsenko, A V" sort="Stetsenko, A V" uniqKey="Stetsenko A" first="A. V." last="Stetsenko">A. V. Stetsenko</name><name sortKey="Stetsenko, A V" sort="Stetsenko, A V" uniqKey="Stetsenko A" first="A. V." last="Stetsenko">A. V. Stetsenko</name><name sortKey="Tatskaya, V N" sort="Tatskaya, V N" uniqKey="Tatskaya V" first="V. N." last="Tatskaya">V. N. Tatskaya</name><name sortKey="Tatskaya, V N" sort="Tatskaya, V N" uniqKey="Tatskaya V" first="V. N." last="Tatskaya">V. N. Tatskaya</name><name sortKey="Yavorskii, A E" sort="Yavorskii, A E" uniqKey="Yavorskii A" first="A. É." last="Yavorskii">A. É. Yavorskii</name><name sortKey="Zavgorodnii, S G" sort="Zavgorodnii, S G" uniqKey="Zavgorodnii S" first="S. G." last="Zavgorodnii">S. G. Zavgorodnii</name><name sortKey="Zavgorodnii, S G" sort="Zavgorodnii, S G" uniqKey="Zavgorodnii S" first="S. G." last="Zavgorodnii">S. G. Zavgorodnii</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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